Screening of Potential Anti-Diabetic Properties of Barbadian Folklore from Medicinal Plants Using Non-conventional and Conventional Drug Targets
| dc.contributor.author | Archer, Kim | |
| dc.date.accessioned | 2022-11-01T15:33:33Z | |
| dc.date.available | 2022-11-01T15:33:33Z | |
| dc.date.issued | 2022-01-28 | |
| dc.description.abstract | Type 2 diabetes can be described as the body’s ineffective use of insulin and it accounts for at least 90% of all diabetic cases. This condition is a multifactorial disease and requires multiple therapeutic approaches, which can lead to prominent irreversible side effects. There are many known classes of drugs for the management of Type 2 diabetes. However, Metformin is used as the oral hypoglycaemic drug of choice for managing the condition. Finding alternative treatments from the plant kingdom is a very viable option. Mormordica charantia (cerasee), Phyllanthus niruri (seed under leaf) and Catharanthus roseus (periwinkle) are all locally grown plants that have been reported anecdotally to exhibit anti-diabetic properties. Their effects on enzymatic drug targets (dipeptidyl peptidase 4 and protein tyrosine phosphatase) to produce better efficacy and safety profiles are being explored. This study incorporates a three-phase drug discovery and preclinical development process to explore potential herbs for the treatment of Type 2 diabetes. Phase 1 includes the collection and extraction of bioactive compounds from the plants. Phase 2 is the in vitro analysis of the extracts on the respective drug targets and it also includes activity guided purification of the bioactive compounds from the extracts. | en_US |
| dc.description.sponsorship | The 9th Annual Faculty of Medical Sciences Graduate Symposium | en_US |
| dc.identifier.uri | https://hdl.handle.net/2139/54429 | |
| dc.language.iso | en | en_US |
| dc.publisher | The University of the West Indies Cave Hill Campus | en_US |
| dc.subject | diabetes | en_US |
| dc.subject | insulin | en_US |
| dc.title | Screening of Potential Anti-Diabetic Properties of Barbadian Folklore from Medicinal Plants Using Non-conventional and Conventional Drug Targets | en_US |
| dc.type | Other | en_US |