Screening of Potential Anti-Diabetic Properties of Barbadian Folklore from Medicinal Plants Using Non-conventional and Conventional Drug Targets
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Date
2022-01-28
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Publisher
The University of the West Indies Cave Hill Campus
Abstract
Type 2 diabetes can be described as the body’s ineffective use of insulin and
it accounts for at least 90% of all diabetic cases. This condition is a multifactorial disease and requires multiple therapeutic approaches, which can lead to prominent irreversible side effects. There are many known classes of drugs for the management of Type 2 diabetes. However, Metformin is used
as the oral hypoglycaemic drug of choice for managing the condition. Finding alternative treatments from the plant kingdom is a very viable option.
Mormordica charantia (cerasee), Phyllanthus niruri (seed under leaf) and
Catharanthus roseus (periwinkle) are all locally grown plants that have been
reported anecdotally to exhibit anti-diabetic properties. Their effects on
enzymatic drug targets (dipeptidyl peptidase 4 and protein tyrosine phosphatase) to produce better efficacy and safety profiles are being explored. This study incorporates a three-phase drug discovery and preclinical development process to explore potential herbs for the treatment of Type 2 diabetes. Phase 1 includes the collection and extraction of bioactive compounds from the plants. Phase 2 is the in vitro analysis of the extracts on the respective drug targets and it also includes activity guided purification of the bioactive compounds from the extracts.
Description
The 9th Annual Faculty of Medical Sciences
Graduate Symposium
Table of Contents
Keywords
diabetes, insulin