Limitations of fasting indices in the measurement of insulin sensitivity in Afro-Caribbean adults

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dc.contributor.authorThompson, Debbie S
dc.contributor.authorBoyne, Michael S
dc.contributor.authorOsmond, Clive
dc.contributor.authorFerguson, Trevor S
dc.contributor.authorTulloch-Reid, Marshall K
dc.contributor.authorWilks, Rainford J
dc.contributor.authorBarnett, Alan T
dc.contributor.authorForrester, Terrence E
dc.date.accessioned2014-04-10T14:24:26Z
dc.date.available2014-04-10T14:24:26Z
dc.date.issued2014-02-20
dc.date.updated2014-04-10T14:24:26Z
dc.description.abstractAbstract Background Insulin sensitivity can be estimated using glucose disposal rate (M) measured during a hyperinsulinemic euglycemic clamp (HEC) or insulin sensitivity index (SI) derived from a frequently sampled intravenous glucose tolerance test (FSIVGTT). The commonly used homeostatic model assessment of insulin resistance (HOMA-IR) which utilizes fasting glucose and insulin has been validated against M across several populations (rand#8201;=and#8201;0.5-0.8). This study sought to validate HOMA-IR against SI and M in an Afro-Caribbean population. Findings Sixty participants completed a 180-minute FSIVGTT and another 50 completed a 150-minute hyperinsulinemic euglycemic clamp. In both groups, HOMA-IR was calculated and anthropometry and body composition using dual energy x-ray absorptiometry (DEXA) were measured.FSIVGTT: The participants were 55% male, age 23.1and#8201;and#177;and#8201;0.05and#160;years, BMI 24.8and#8201;and#177;and#8201;6.3and#160;kg/m2 and % body fat 25.0and#8201;and#177;and#8201;15.2 (meanand#8201;and#177;and#8201;SD). HEC: The participants were 44% male, age 27.3and#8201;and#177;and#8201;8.1and#160;years, BMI 23.6and#8201;and#177;and#8201;5.0and#160;kg/m2 and % body fat 24.7and#8201;and#177;and#8201;14.2 (meanand#8201;and#177;and#8201;SD). While HOMA-IR, SI and M correlated with waist, BMI and % body fat (P-valuesand#8201;andlt;and#8201;0.01) there were no significant correlations between HOMA-IR with either SI or M-value (P-valuesand#8201;andgt;and#8201;0.2). Conclusions In young Afro-Caribbean adults, HOMA-IR compared poorly with other measures of insulin sensitivity. It remains important to determine whether similar findings occur in a more insulin resistant population. However, HOMA-IR correlated with clinical measures of insulin sensitivity (i.e. adiposity), so it may still be useful in epidemiological studies.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Research Notes. 2014 Feb 20;7(1):98
dc.identifier.urihttp://dx.doi.org/10.1186/1756-0500-7-98
dc.identifier.urihttps://hdl.handle.net/2139/38043
dc.language.rfc3066en
dc.rights.holderDebbie S Thompson et al.; licensee BioMed Central Ltd.
dc.titleLimitations of fasting indices in the measurement of insulin sensitivity in Afro-Caribbean adults
dc.typeJournal Article

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