Limitations of fasting indices in the measurement of insulin sensitivity in Afro-Caribbean adults

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dc.contributor.author Thompson, Debbie S
dc.contributor.author Boyne, Michael S
dc.contributor.author Osmond, Clive
dc.contributor.author Ferguson, Trevor S
dc.contributor.author Tulloch-Reid, Marshall K
dc.contributor.author Wilks, Rainford J
dc.contributor.author Barnett, Alan T
dc.contributor.author Forrester, Terrence E
dc.date.accessioned 2014-04-10T14:24:26Z
dc.date.available 2014-04-10T14:24:26Z
dc.date.issued 2014-02-20
dc.identifier.citation BMC Research Notes. 2014 Feb 20;7(1):98
dc.identifier.uri http://dx.doi.org/10.1186/1756-0500-7-98
dc.identifier.uri http://hdl.handle.net/2139/38043
dc.description.abstract Abstract Background Insulin sensitivity can be estimated using glucose disposal rate (M) measured during a hyperinsulinemic euglycemic clamp (HEC) or insulin sensitivity index (SI) derived from a frequently sampled intravenous glucose tolerance test (FSIVGTT). The commonly used homeostatic model assessment of insulin resistance (HOMA-IR) which utilizes fasting glucose and insulin has been validated against M across several populations (rand#8201;=and#8201;0.5-0.8). This study sought to validate HOMA-IR against SI and M in an Afro-Caribbean population. Findings Sixty participants completed a 180-minute FSIVGTT and another 50 completed a 150-minute hyperinsulinemic euglycemic clamp. In both groups, HOMA-IR was calculated and anthropometry and body composition using dual energy x-ray absorptiometry (DEXA) were measured.FSIVGTT: The participants were 55% male, age 23.1and#8201;and#177;and#8201;0.05and#160;years, BMI 24.8and#8201;and#177;and#8201;6.3and#160;kg/m2 and % body fat 25.0and#8201;and#177;and#8201;15.2 (meanand#8201;and#177;and#8201;SD). HEC: The participants were 44% male, age 27.3and#8201;and#177;and#8201;8.1and#160;years, BMI 23.6and#8201;and#177;and#8201;5.0and#160;kg/m2 and % body fat 24.7and#8201;and#177;and#8201;14.2 (meanand#8201;and#177;and#8201;SD). While HOMA-IR, SI and M correlated with waist, BMI and % body fat (P-valuesand#8201;andlt;and#8201;0.01) there were no significant correlations between HOMA-IR with either SI or M-value (P-valuesand#8201;andgt;and#8201;0.2). Conclusions In young Afro-Caribbean adults, HOMA-IR compared poorly with other measures of insulin sensitivity. It remains important to determine whether similar findings occur in a more insulin resistant population. However, HOMA-IR correlated with clinical measures of insulin sensitivity (i.e. adiposity), so it may still be useful in epidemiological studies.
dc.title Limitations of fasting indices in the measurement of insulin sensitivity in Afro-Caribbean adults
dc.type Journal Article
dc.date.updated 2014-04-10T14:24:26Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Debbie S Thompson et al.; licensee BioMed Central Ltd.


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