Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk

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dc.contributor.author Luke, Amy
dc.contributor.author Bovet, Pascal
dc.contributor.author Forrester, Terrence E
dc.contributor.author Lambert, Estelle V
dc.contributor.author Plange-Rhule, Jacob
dc.contributor.author Schoeller, Dale A
dc.contributor.author Dugas, Lara R
dc.contributor.author Durazo-Arvizu, Ramon A
dc.contributor.author Shoham, David
dc.contributor.author Cooper, Richard S
dc.contributor.author Brage, Soren
dc.contributor.author Ekelund, Ulf
dc.contributor.author Steyn, Nelia
dc.date.accessioned 2012-03-30T05:33:15Z
dc.date.available 2012-03-30T05:33:15Z
dc.date.issued 2011-12-14
dc.identifier http://dx.doi.org/10.1186/1471-2458-11-927
dc.identifier.citation BMC Public Health. 2011 Dec 14;11(1):927
dc.identifier.uri http://hdl.handle.net/2139/12621
dc.description.abstract Abstract Background The prevalence of obesity has increased in societies of all socio-cultural backgrounds. To date, guidelines set forward to prevent obesity have universally emphasized optimal levels of physical activity. However there are few empirical data to support the assertion that low levels of energy expenditure in activity is a causal factor in the current obesity epidemic are very limited. Methods/Design The Modeling the Epidemiologic Transition Study (METS) is a cohort study designed to assess the association between physical activity levels and relative weight, weight gain and diabetes and cardiovascular disease risk in five population-based samples at different stages of economic development. Twenty-five hundred young adults, ages 25-45, were enrolled in the study; 500 from sites in Ghana, South Africa, Seychelles, Jamaica and the United States. At baseline, physical activity levels were assessed using accelerometry and a questionnaire in all participants and by doubly labeled water in a subsample of 75 per site. We assessed dietary intake using two separate 24-hour recalls, body composition using bioelectrical impedance analysis, and health history, social and economic indicators by questionnaire. Blood pressure was measured and blood samples collected for measurement of lipids, glucose, insulin and adipokines. Full examination including physical activity using accelerometry, anthropometric data and fasting glucose will take place at 12 and 24 months. The distribution of the main variables and the associations between physical activity, independent of energy intake, glucose metabolism and anthropometric measures will be assessed using cross-section and longitudinal analysis within and between sites. Discussion METS will provide insight on the relative contribution of physical activity and diet to excess weight, age-related weight gain and incident glucose impairment in five populations' samples of young adults at different stages of economic development. These data should be useful for the development of empirically-based public health policy aimed at the prevention of obesity and associated chronic diseases.
dc.title Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk
dc.type Journal Article
dc.date.updated 2012-03-30T05:33:15Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Luke et al.; licensee BioMed Central Ltd.


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